Lori J West
Departments: Department of Pediatrics, Department of Surgery, Department of Medical Microbiology & Immunology
Degrees: MD, DPhil, FRCPC
Office: Alberta Diabetes Institute, 6-002C HRIF East
Tel: 780.492.3200
Fax: 780.492.8239
E-mail:
Positions
University of Alberta
Professor, Pediatrics, Surgery and Immunology
Director of Heart Transplantation Research
External
Alberta Heritage Foundation for Medical Research Senior Scholar
Canada Research Chair in Cardiac Transplantation
Past President, Canadian Society for Transplantation
Councilor-at-Large, Board of Directors, American Society of Transplantation
Chair, Institute Advisory Board, Canadian Institutes of Health Research (CIHR) -Institute of Circulatory and Respiratory Health (ICRH)
Member, Board of Directors; Chair, Program Committee XXVII Annual Meeting (2007-2008), International Society of Heart and Lung Transplantation (ISHLT)
Research Area
immune tolerance and transplant immunology
Research Synopsis
The overarching goal of the Transplant Immunology Research Program directed by Dr. West at the University of Alberta is the development of a comprehensive research focus encompassing specific projects related to transplantation.
These projects range from molecular level 'gene therapy' and cell biology investigations in murine transplant models through to clinical projects that include patient and population outcomes, quality-of-life studies and clinical drug trials. Bi-directional translational research is a crucial component in this regard, bridging the basic laboratory with the clinic.
Keywords
immune tolerance, transplant imunology
Selected Publications
PA = Principal Author
SRI = Senior Responsible Investigator
CPA = Co-Principal Author
C = Collaborator
KJ Wood, AR Bushell, CR Darby, TC Pearson, LJ West, PJ Morris. Mechanism of induction of transplantation tolerance using donor antigen and anti-CD4 monoclonal antibody. Transplantation Proceedings. 23(1 Pt 1): 133-134, 1991. C
TC Pearson, AR Bushell, CR Darby, LJ West, PJ Morris, KJ Wood. Lymphocyte changes associated with prolongation of cardiac allograft survival in adult mice using anti-CD4 monoclonal antibody. Clinical and Experimental Immunology. 92(2): 211-217, 1993. C
TC Pearson, CR Darby, A Bushell, LJ West, PJ Morris, KJ Wood. The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the murine model. Transplantation. 55(2): 361-367, 1993. C
LJ West, PJ Morris, KJ Wood. Fetal liver haematopoietic cells and tolerance to organ allografts. The Lancet. 343(8890): 148-149, 1994. PA
LJ West, PJ Morris, KJ Wood. Neonatally induced transplantation tolerance to primarily vascularised cardiac allografts is not donor-specific. Transplantation Proceedings. 27(1): 184-185, 1995. PA
L Dror, M Greenberg, G Taylor, R Superina, D Hebert, LJ West, B Connolly, L Sena, U Allen, S Weitzman. Lymphoproliferative disorders after organ transplantation in children. Transplantation. 67(7): 990-998, 1999.C
SH Borenstein. K Tao, LJ West, JW Chamberlain. Extrathymic deletion of CD8+ alloreactive T cells in a transgenic T cell receptor model of neonatal tolerance. Transplantation. 72(11): 1807-1816, 2001. C
LJ West, SM Pollock-BarZiv, AI Dipchand, KJ Lee, CJ Cardella, IM Rebeyka, LN Benson, JG Coles. ABO-incompatible heart transplantation in infants. The New England Journal of Medicine. 344(11): 793-800, 2001. PA [article accompanied by editorial]
G Dellgren, B Koirala, A Sakopoulus, A Botta, J Joseph, L Benson, B McCrindle, A Dipchand, C Cardella, KJ Lee, LJ West, N Poirer, GS VanArsdell, WG Williams, JG Coles. Pediatric heart transplantation: improving results in high-risk patients. Journal of Thoracic and Cardiovascular Surgery. 121(4): 782-791, 2001.C
LJ West. Defining critical windows in the development of the human immune system. Human and Experimental Toxicology. 21(9-10): 499-505, 2002. Review PA
LJ West. Developmental aspects of immunomodulation: exploiting the immature immune system for organ transplantation. Transplant Immunology. 9: 149-153, 2002. PA
LJ West, K Tao. Acceptance of third-party cardiac, but not skin allografts induced by neonatal exposure to semi-allogeneic lymphohematopoietic cells. American Journal of Transplantation. 2(8): 733-744, 2002. PA
MP Holsapple, LJ West, KS Landreth. Species comparison of anatomical and functional immune system development. Birth Defects Research (Part B). 68: 321-334, 2003. C
BM Ogle, M Cascalho, C Joao, W Taylor, LJ West, JL Platt. Direct measurement of lymphocyte receptor diversity. Nucleic Acids Research, 31(22): e139, 2003. C
MP Holsapple, DJ Paustenback, G Charnley, LJ West, MI Luster, RR Dietert, LA Burns-Naas. Symposium summary: children's health risk - what's so special about the developing immune system? Toxicology and Applied Pharmacology. 199(1): 61-70, 2004. C
SH Borenstein, KS Tao, N Hu, LJ West, JW Chamberlain. Induction of xenogeneic neonatal tolerance to transgenic human leukocyte antigen class I grafts. Transplantation. 78(6): 844-852, 2004. C
B Hofmann, K Tao, L Mai L, LJ West. Acceptance of related and unrelated cardiac allografts in neonatally-tolerized mice is cardio-specific and transferable by regulatory CD4+ T cells. Journal of Heart and Lung Transplantation. 23: 1069-76, 2004. SRI
X Fan, A Ang, SM Pollock-BarZiv, AI Dipchand, P Ruiz, G Wilson, JL Platt, LJ West. Donor-specific B cell tolerance after ABO-incompatible infant heart transplantation. Nature Medicine. 10(11): 1227-1233, 2004. SRI (article accompanied by a 'News and Views' commentary)
M Yoshimitsu, T Sato, K Tao, J Walia, VI Rasaiah, GT Sleep, GJ Murray, AG Poeppl, J Underwood, LJ West, RO Brady, JA Medin. Bioluminescent imaging of a marking transgene and correction of Fabry mice by neonatal injection of recombinant lentiviral vectors. Proceedings of the National Academy of Sciences. 101(48): 16909-14, 2004. C
X Fan, K Tyerman, A Ang, K Koo, K Parameswaran, K Tao, L Mai, H Lang, LJ West. A novel tool for B cell tolerance research: characterization of mouse alloantibody development using a simple and reliable cellular ELISA technique. Transplantation Proceedings. 37: 29-31, 205. SRI
LJ West. Targeting an antibody-mediated rejection in the setting of ABO-incompatible infant heart transplantation: graft accommodation vs. B cell tolerance. Current Drug Targets - Cardiovascular and Hematological Disorders. (3): 223-232, 2005. PA
X Fan, A Ang, LJ West. Successful 'transplantation' of human ABO blood group system to mouse by gene therapy using lentiviral vector harboring human ABH related transferase genes: a novel animal model for ABO incompatible heart transplantation research. Transplantation Proceedings. 2005. SRI
LJ West. ABO-incompatible heart transplantation: an alternative to improve the donor shortage in infants. Current Opinion in Organ Transplantation, 10(4): 364-368, 2005.PA
X Fan, A Ang, K Tao, LJ West. Induction of human histo-blood group A antigen expression in mouse cells by gene therapy using lentiviral vectors harbouring human ABH-related glycosyltransferase genes. Transplantation Proceedings. 37: 265-267, 2005. SRI
BM Ogle, LJ West, DJ Driscoll, SE Strome, RR Razonable, CV Paya, M Cascalho, JL Platt. Effacing of the T cell compartment by cardiac transplantation in infancy. Journal of Immunology. 176: 1962-1967, 2006. C
LJ West. B cell tolerance following ABO-incompatible infant heart transplantation. Transplantation. 81(3): 301-307, 2006. PA
G Stussi, LJ West, DKC Cooper, JD Seebach. ABO-incompatible allotransplantation as a basis for clinical xenotransplantation. Xenotransplanation. 13(5): 390-9, 2006. C
Departmental Website: http://www.cardiactransplantresearch.med.ualberta.ca/
